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- Title
Antimicrobial Resistance in Livestock: A Serious Threat to Public Health.
- Authors
Bava, Roberto; Castagna, Fabio; Lupia, Carmine; Poerio, Giusi; Liguori, Giovanna; Lombardi, Renato; Naturale, Maria Diana; Mercuri, Caterina; Bulotta, Rosa Maria; Britti, Domenico; Palma, Ernesto
- Abstract
Antimicrobial resistance represents an alarming public health problem; its importance is related to the significant clinical implications (increased morbidity, mortality, disease duration, development of comorbidities, and epidemics), as well as its economic effects on the healthcare sector. In fact, therapeutic options are severely limited by the advent and spread of germs resistant to many antibiotics. The situation worldwide is worrying, especially in light of the prevalence of Gram-negative bacteria—Klebsiella pneumoniae and Acinetobacter baumannii—which are frequently isolated in hospital environments and, more specifically, in intensive care units. The problem is compounded by the ineffective treatment of infections by patients who often self-prescribe therapy. Resistant bacteria also show resistance to the latest generation antibiotics, such as carbapenems. In fact, superbacteria, grouped under the acronym extended-spectrum betalactamase (ESBL), are becoming common. Antibiotic resistance is also found in the livestock sector, with serious repercussions on animal production. In general, this phenomenon affects all members of the biosphere and can only be addressed by adopting a holistic "One Health" approach. In this literature overview, a stock is taken of what has been learned about antibiotic resistance, and suggestions are proposed to stem its advance.
- Subjects
DRUG resistance in microorganisms; KLEBSIELLA pneumoniae; PUBLIC health; DRUG resistance in bacteria; ACINETOBACTER baumannii; INFECTIOUS disease transmission; INTENSIVE care units; KLEBSIELLA infections
- Publication
Antibiotics (2079-6382), 2024, Vol 13, Issue 6, p551
- ISSN
2079-6382
- Publication type
Article
- DOI
10.3390/antibiotics13060551