We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Bacillus coagulans BACO-17 Alone or in Combination with Galacto-Oligosaccharide Ameliorates Salmonella -Induced Diarrhea and Intestinal Inflammation.
- Authors
Wu, Min-Zi; Sun, Tsai-Chien; Huang, Yu-Wen; Wu, Yi-Ching; Chen, Wei-Jen; Chu, Hui-Fang; Liu, Cheng-Yen; Chau, Chi-Fai
- Abstract
In this study, a diarrhea model was established by exposing rats to appropriate antibiotics and Salmonella. After an in vitro screening of prebiotics, fructo-oligosaccharide and galacto-oligosaccharide (GOS) were selected; their synbiotic potential and ability to ameliorate diarrhea symptoms and intestinal inflammation with Bacillus coagulans BACO-17 were evaluated in vivo. After a 27-day feeding experiment including antibiotic intervention and Salmonella infection, it was found that using B. coagulans BACO-17 alone and in combination with GOS as a synbiotic could render a better recovery by lowering diarrhea indexes by 26.9% and 18.7%, respectively. Compared with the negative control, the administration of this synbiotic mixture resulted in the most significant increase in fecal concentrations of total short-chain fatty acids (about 2-fold higher), with a promising improvement in disrupted gut microbial balance. It was worth noting that the administration of B. coagulans BACO-17 alone or in combination with GOS effectively reduced intestinal inflammation (27–31%) and mucosal necrosis (82%) over the negative control. These results suggested that B. coagulans BACO-17 and GOS could be exploited as a promising synbiotic mixture to relieve intestinal inflammatory diseases and improve gut health.
- Subjects
BACILLUS (Bacteria); OLIGOSACCHARIDES; DIARRHEA; SALMONELLA diseases; SHORT-chain fatty acids; INTESTINES; SALMONELLA typhimurium; SALMONELLA
- Publication
Processes, 2022, Vol 10, Issue 10, pN.PAG
- ISSN
2227-9717
- Publication type
Article
- DOI
10.3390/pr10102123