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- Title
Epidemiology of Gliomas in Israel: A Nationwide Study.
- Authors
Sadetzki, Siegal; Zach, Leor; Chetrit, Angela; Nass, Dvora; Hoffmann, Chen; Ram, Zvi; Zaaroor, Menashe; Umansky, Felix; Rappaport, Zvi Harry; Cohen, Avi; Wald, Uriel; Rothman, Sigmund; Hadani, Moshe
- Abstract
Background: Glial brain tumors span a wide range of neoplasms with distinct clinical and histopathological features. This report presents the descriptive epidemiology of glial tumors by histological subtype and tumor behavior. Methods: The study population included all incident cases of glial tumors diagnosed in Israel during March 2001 to July 2003. Age-standardized incidence rates (ASR) were calculated using the world population as a standard. Results: A total of 548 tumors were diagnosed, of which 520 had histological confirmation. The ASR of all adult (>20 years) glial tumors was 5.82/100,000 (7.11 for males; 4.75 for females, p < 0.001). The majority of tumors (78%) were classified as high grade; astrocytic tumors were the most frequent (85%), with glioblastoma multiforme accounting for 70% of them. A significant positive association was shown between age at diagnosis and grade. The highest ASR was seen for Europe- and-American-born, followed by Israeli, Asian and African-born individuals (6.78, 5.86, 4.94 and 3.84/100,000, respectively). Conclusions: In general, these results describing data of incident cases of pathologically validated glial tumors are consistent with previous reports. To enhance our understanding of these diseases, epidemiological studies should rely on well-defined histological tumor types, incorporating comprehensive information which will allow comparability between different groups of patients. Copyright © 2008 S. Karger AG, Basel
- Publication
Neuroepidemiology, 2008, Vol 31, Issue 4, p264
- ISSN
0251-5350
- Publication type
Article
- DOI
10.1159/000165366