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- Title
Clinical Features and Prognosis of Nontuberculous Mycobacterial Pleuritis: A Multicenter Retrospective Study.
- Authors
Kazuma Yagi; Akihiro Ito; Keiji Fujiwara; Eriko Morino; Isano Hase; Yasushi Nakano; Takanori Asakura; Koji Furuuchi; Atsuho Morita; Takahiro Asami; Ho Namkoong; Fumitake Saito; Kozo Morimoto; Makoto Ishii; Yasunori Sato; Hiroki Tateno; Kazumi Nishio; Yoshitaka Oyamada; Koichi Fukunaga; Haruhito Sugiyama
- Abstract
Rationale: The clinical features and prognosis of nontuberculous mycobacterial (NTM) pleuritis and pleural effusion combined with NTM lung disease remain unclear. Objectives: To investigate the clinical features and prognosis of NTM pleuritis. Methods: This retrospective observational study included patients with NTM pleuritis from January 2001 to June 2018 across eight hospitals in Japan. NTM pleuritis was defined by a positive NTM culture of pleural effusion samples. We matched patients with Mycobacterium avium complex (MAC) lung disease (MAC-LD) without pleuritis by sex and age to obtain comparative data and investigated the association between clinical parameters and the prognosis. Results: We identified 64 patients with NTM pleuritis (median age, 73 yr; 37 female patients). The median follow-up duration was 11 months, and 27 patients died. Patients with MAC pleuritis had a significantly lower survival rate than matched patients with MAC-LD without pleuritis. Multivariate analysis revealed that pleuritis (adjusted hazard ratio, 6.99; 95% confidence interval [CI], 2.58-19.00) and underlying pulmonary diseases (adjusted hazard ratio, 3.01; 95% CI, 1.44-6.28) were independently associated with all-cause mortality in patients with MAC-LD. Conclusions: The prognosis of MAC pleuritis is poorer than that of MAC-LD without pleuritis. Pleuritis is an independent prognostic factor in patients with MAC-LD.
- Subjects
MYCOBACTERIAL disease diagnosis; MYCOBACTERIAL disease treatment; PLEURISY; MYCOBACTERIUM avium; PLEURAL effusions
- Publication
Annals of the American Thoracic Society, 2021, Vol 18, Issue 9, p1490
- ISSN
2329-6933
- Publication type
journal article
- DOI
10.1513/AnnalsATS.202008-938OC