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- Title
Tacrolimus and diarrhea: Pathogenesis of altered metabolism.
- Authors
Mittal, Naveen; Thompson, John F.; Kato, Tomoaki; Tzakis, Andreas G.
- Abstract
Editorial. Discusses the role of the intestines in the metabolism of tacrolimus in organ transplanted children. Explanations for the rise in blood levels of tacrolimus; Overlap between CYP3A, a major Phase I xenobiotic enzyme known to metabolize tacrolimus and P-glycoprotein substrates and modulators; Effect of rotaviral illness on intestinal or hepatic CYP3A in human and animals.
- Subjects
INTESTINES; TACROLIMUS; DRUG metabolism; TRANSPLANTATION of organs, tissues, etc. in children; P-glycoprotein
- Publication
Pediatric Transplantation, 2001, Vol 5, Issue 2, p75
- ISSN
1397-3142
- Publication type
Editorial
- DOI
10.1034/j.1399-3046.2001.005002075.x