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- Title
Routine detection of serum antidesmocollin autoantibodies is only useful in patients with atypical pemphigus.
- Authors
Mindorf, Swantje; Dettmann, Inga M.; Krüger, Stine; Fuhrmann, Tarek; Rentzsch, Kristin; Karl, Ingolf; Probst, Christian; Komorowski, Lars; Fechner, Kai; Beek, Nina; Lemcke, Susanne; Sárdy, Miklós; Bangert, Christine; Benoit, Sandrine; Hashimoto, Takashi; Zillikens, Detlef; Pas, Hendri H.; Jonkman, Marcel F.; Stöcker, Winfried; Schmidt, Enno
- Abstract
Autoantibodies against the 3 desmocollin (Dsc; Dsc1-Dsc3) isoforms have been described in different pemphigus variants. Here, we developed state-of-the-art detection systems for serum anti-Dsc1, Dsc2 and Dsc1 IgG and IgA. These assays were applied in 5 different cohorts including pemphigus vulgaris ( PV) patients with compatible direct immunofluorescence ( IF) microscopy but no reactivity against desmogleins 1 and 3 (n = 24) and sera from patients with autoimmune blistering diseases with positive direct IF microscopy taken at the time of diagnosis (n = 749). We found that detection of anti-Dsc serum reactivity is not helpful in the routine diagnosis of PV, pemphigus foliaceus and paraneoplastic pemphigus but may be valuable in pemphigus vegetans.
- Subjects
AUTOANTIBODIES; PEMPHIGUS; IMMUNOFLUORESCENCE; MONOCLONAL antibodies; IMMUNOGLOBULIN G
- Publication
Experimental Dermatology, 2017, Vol 26, Issue 12, p1267
- ISSN
0906-6705
- Publication type
Article
- DOI
10.1111/exd.13409