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- Title
Real-time magnetic resonance imaging – guided coronary intervention in a porcine model.
- Authors
Heidt, Timo; Reiss, Simon; Krafft, Axel J.; Özen, Ali Caglar; Lottner, Thomas; Hehrlein, Christoph; Galmbacher, Roland; Kayser, Gian; Hilgendorf, Ingo; Stachon, Peter; Wolf, Dennis; Zirlik, Andreas; Düring, Klaus; Zehender, Manfred; Meckel, Stephan; von Elverfeldt, Dominik; Bode, Christoph; Bock, Michael; Mühlen, Constantin von zur
- Abstract
X-ray fluoroscopy is the gold standard for coronary diagnostics and intervention. Magnetic resonance imaging is a radiation-free alternative to x-ray with excellent soft tissue contrast in arbitrary slice orientation. Here, we assessed real-time MRI-guided coronary interventions from femoral access using newly designed MRI technologies. Six Goettingen minipigs were used to investigate coronary intervention using real-time MRI. Catheters were custom-designed and equipped with an active receive tip-coil to improve visibility and navigation capabilities. Using modified standard clinical 5 F catheters, intubation of the left coronary ostium was successful in all animals. For the purpose of MR-guided coronary interventions, a custom-designed 8 F catheter was used. In spite of the large catheter size, and therefore limited steerability, intubation of the left coronary ostium was successful in 3 of 6 animals within seconds. Thereafter, real-time guided implantation of a non-metallic vascular scaffold into coronary arteries was possible. This study demonstrates that real-time MRI-guided coronary catheterization and intervention via femoral access is possible without the use of any contrast agents or radiation, including placement of non-metallic vascular scaffolds into coronary arteries. Further development, especially in catheter and guidewire technology, will be required to drive forward routine MR-guided coronary interventions as an alternative to x-ray fluoroscopy.
- Publication
Scientific Reports, 2019, Vol 9, Issue 1, pN.PAG
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/s41598-019-45154-7