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- Title
Association study of semaphorin 7a (sema7a) polymorphisms with bone mineral density and fracture risk in postmenopausal Korean women.
- Authors
Jung-Min Koh; Bermseok Oh; Jong Yong Lee; Jong-Keuk Lee; Kimm, Kuchan; Ghi Su Kim; Byung Lae Park; Hyun Sub Cheong; Hyoung Doo Shin; Jung Min Hong; Tae-Ho Kim; Eui Kyun Park; Shin-Yoon Kim
- Abstract
Bone mineral density (BMD), the major factor determining bone strength, is closely related to osteoporotic fracture risk and is determined largely by multiple genetic factors. Semaphorin 7a (SEMA7A), a recently described member of the semaphorin family, has been shown to play a critical role in the activation of monocyte/macrophages that share progenitors with bone-resorbing osteoclasts and thus might contribute to osteoclast development. In the present study, we directly sequenced the SEMA7A gene in 24 Korean individuals, and identified 15 sequence variants. Five polymorphisms (+15667G>A, +15775C>G, +16285C>T, +19317C>T, +22331A>G) were selected and genotyped in postmenopausal Korean women ( n=560) together with measurement of the areal BMD (g/cm2) of the anterior-posterior lumbar spine and the non-dominant proximal femur using dual-energy X-ray absorptiometry. We found that polymorphisms of the SEMA7A gene were associated with the BMD of the lumbar spine and femoral neck. SEMA7A+15775C>G and SEMA7A+22331A>G were associated with low BMD of the femoral neck ( P=0.02) and lumbar spine ( P=0.04) in a recessive model. SEMA7A-ht4 also showed an association with risk of vertebral fracture (OR=1.87–1.93, P=0.02–0.03). Our results suggest that variations in SEMA7A may play a role in decreased BMD and risk of vertebral fracture.
- Subjects
SOUTH Korea; MENOPAUSE; CLIMACTERIC; GENETIC polymorphisms; BONE fractures; WOMEN'S injuries
- Publication
Journal of Human Genetics, 2006, Vol 51, Issue 2, p112
- ISSN
1434-5161
- Publication type
Article
- DOI
10.1007/s10038-005-0331-z