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- Title
Fatal Human Neurologic Infection Caused by Pigeon Avian Paramyxovirus-1, Australia.
- Authors
Hurley, Siobhan; Eden, John Sebastian; Bingham, John; Rodriguez, Michael; Neave, Matthew J.; Johnson, Alexandra; Howard-Jones, Annaleise R.; Kok, Jen; Anazodo, Antoinette; McMullan, Brendan; Williams, David T.; Watson, James; Solinas, Annalisa; Ki Wook Kim; Rawlinson, William
- Abstract
Avian paramyxovirus type 1 (APMV-1) is a virus of birds that results in a range of outcomes, from asymptomatic infections to outbreaks of systemic respiratory and neurologic disease, depending on the virus strain and the avian species affected. Humans are rarely affected; those who are predominantly experience mild conjunctivitis. We report a fatal case of neurologic disease in a 2-year-old immunocompromised child in Australia. Metagenomic sequencing and histopathology identified the causative agent as the pigeon variant of APMV-1. This diagnosis should be considered in neurologic conditions of undefined etiologies. Agnostic metagenomic sequencing methods are useful in such settings to direct diagnostic and therapeutic efforts.
- Publication
Emerging Infectious Diseases, 2023, Vol 29, Issue 12, p2482
- ISSN
1080-6040
- Publication type
Article
- DOI
10.3201/eid2912.230250