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- Title
Trends in Incidence and Clinical Outcomes of Clostridioides difficile Infection, Hong Kong.
- Authors
Guo, Cosmos L. T.; Kwong, Thomas N. Y.; Mak, Joyce W. Y.; Lin Zhang; Lui, Grace C. Y.; Wong, Grace L. H.; Ip, Margaret; Jun Yu; Sung, Joseph J. Y.; Wu, William K. K.; Wong, Sunny H.
- Abstract
We conducted a territory wide survey to investigate the epidemiology, risk factors, and clinical outcomes of Clostridioides difficile infection (CDI) among hospitalized patients in Hong Kong. A total of 17,105 cases of CDI were identified, of which 15,717 (91.9%) were healthcare-associated and 1,025 (6.0%) were community-associated. Although CDI incidence increased substantially from 2006 to 2017, it plateaued in 2018 and 2019. The 30-day mortality rates decreased from 20.1% in 2015 to 16.8% in 2019, whereas the 60-day recurrence rates remained constant at ≈11% during the study period. Cross-correlation statistic showed significant correlations between incidence trend and overall antimicrobial drug use (r = 0.865, p<0.001), which has decreased as a result of an antibiotic stewardship program initiated in 2017. Our data suggest a turning point in C. difficile epidemiology that could be related to the changing pattern of antimicrobial drug use.
- Subjects
HONG Kong (China); CLOSTRIDIOIDES difficile; TREATMENT effectiveness; DRUG utilization; ANTIMICROBIAL stewardship; ANTI-infective agents
- Publication
Emerging Infectious Diseases, 2021, Vol 27, Issue 12, p3036
- ISSN
1080-6040
- Publication type
Article
- DOI
10.3201/eid2712.203769