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- Title
Reemergence of Reston ebolavirus in Cynomolgus Monkeys, the Philippines, 2015.
- Authors
Demetria, Catalino; Smith, Ina; Tan, Titus; Villarico, Daniel; Simon, Edson Michael; Centeno, Rex; Tachedjian, Mary; Satoshi Taniguchi; Masayuki Shimojima; Miranda, Noel Lee J.; Miranda, Mary Elizabeth; Rondina, Melissa Marie R.; Capistrano, Rowena; Tandoc III, Amado; Marsh, Glenn; Eagles, Debbie; Cruz, Ramses; Shuetsu Fukushi; Taniguchi, Satoshi; Shimojima, Masayuki
- Abstract
In August 2015, a nonhuman primate facility south of Manila, the Philippines, noted unusual deaths of 6 cynomolgus monkeys (Macaca fascicularis), characterized by generalized rashes, inappetence, or sudden death. We identified Reston ebolavirus (RESTV) infection in monkeys by using serologic and molecular assays. We isolated viruses in tissues from infected monkeys and determined viral genome sequences. RESTV found in the 2015 outbreak is genetically closer to 1 of the 4 RESTVs that caused the 2008 outbreak among swine. Eight macaques, including 2 also infected with RESTV, tested positive for measles. Concurrently, the measles virus was circulating throughout the Philippines, indicating that the infection of the macaques may be a reverse zoonosis. Improved biosecurity measures will minimize the public health risk, as well as limit the introduction of disease and vectors.
- Subjects
EBOLA virus disease; KRA; SUDDEN death; SERODIAGNOSIS; ENZYME-linked immunosorbent assay; VIRAL genomes; SEQUENCE analysis; ZOONOSES
- Publication
Emerging Infectious Diseases, 2018, Vol 24, Issue 7, p1285
- ISSN
1080-6040
- Publication type
journal article
- DOI
10.3201/eid2407.171234