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- Title
MERS-CoV Antibody Responses 1 Year after Symptom Onset, South Korea, 2015.
- Authors
Pyoeng Gyun Choe; Perera, R. A. P. M.; Wan Beom Park; Kyoung-Ho Song; Ji Hwan Bang; Eu Suk Kim; Hong Bin Kim; Ko, Long Wei Ronald; Sang Won Park; Nam-Joong Kim; Lau, Eric H. Y.; Poon, Leo L. M.; Peiris, Malik; Myoung-don Oh; Choe, Pyoeng Gyun; Park, Wan Beom; Song, Kyoung-Ho; Bang, Ji Hwan; Kim, Eu Suk; Kim, Hong Bin
- Abstract
We investigated the kinetics of the Middle East respiratory syndrome coronavirus (MERS-CoV) neutralizing and spike protein antibody titers over the course of 1 year in 11 patients who were confirmed by reverse transcription PCR to have been infected during the outbreak in South Korea in 2015. Robust antibody responses were detected in all survivors who had severe disease; responses remained detectable, albeit with some waning, for <1 year. The duration of viral RNA detection (but not viral load) in sputum significantly correlated with the antibody response magnitude. The MERS S1 ELISA antibody titers correlated well with the neutralizing antibody response. Antibody titers in 4 of 6 patients who had mild illness were undetectable even though most had evidence of pneumonia. This finding implies that MERS-CoV seroepidemiologic studies markedly underestimate the extent of mild and asymptomatic infection. Obtaining convalescent-phase plasma with high antibody titers to treat MERS will be challenging.
- Subjects
MIDDLE East respiratory syndrome; MERS coronavirus; ANTIBODY titer; RNA viruses; INFECTION
- Publication
Emerging Infectious Diseases, 2017, Vol 23, Issue 7, p1079
- ISSN
1080-6040
- Publication type
journal article
- DOI
10.3201/eid2307.170310