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- Title
Enterovirus D68 Infection in Children with Acute Flaccid Myelitis, Colorado, USA, 2014.
- Authors
Aliabadi, Negar; Messacar, Kevin; Pastula, Daniel M.; Robinson, Christine C.; Leshem, Eyal; Sejvar, James J.; Allan Nix, W.; Steven Oberste, M.; Feikin, Daniel R.; Dominguez, Samuel R.; Nix, W Allan; Oberste, M Steven
- Abstract
During August 8, 2014-October 14, 2014, a total of 11 children with acute flaccid myelitis and distinctive neuroimaging changes were identified near Denver, Colorado, USA. A respiratory prodrome was experienced by 10, and nasopharyngeal specimens were positive for enterovirus D68 (EV-D68) for 4. To determine whether an association exists between EV-D68 infection and acute flaccid myelitis, we conducted a retrospective case-control study comparing these patients with 2 groups of outpatient control children (1 group tested for acute respiratory illness and 1 for Bordetella pertussis infection). Adjusted analyses indicated that, for children with acute flaccid myelitis, the odds of having EV-D68 infection were 10.3 times greater than for those tested for acute respiratory infection and 4.5 times greater than for those tested for B. pertussis infection. No statistical association was seen between acute flaccid myelitis and non-EV-D68 enterovirus or rhinovirus infection. These findings support an association between EV-D68 infection and acute flaccid myelitis.
- Subjects
COLORADO; ENTEROVIRUS diseases; ACUTE flaccid paralysis; RHINOVIRUSES; PICORNAVIRUS infections; MUSCLE hypotonia; WHOOPING cough; ENTEROVIRUSES; EPIDEMICS; MYELITIS; TIME; RETROSPECTIVE studies; CASE-control method
- Publication
Emerging Infectious Diseases, 2016, Vol 22, Issue 8, p1387
- ISSN
1080-6040
- Publication type
journal article
- DOI
10.3201/eid2208.151949