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- Title
Identifying LRRC16B as an oncofetal gene with transforming enhancing capability using a combined bioinformatics and experimental approach.
- Authors
Hsu, C-C; Chiang, C-W; Cheng, H-C; Chang, W-T; Chou, C-Y; Tsai, H-W; Lee, C-T; Wu, Z-H; Lee, T-Y; Chao, A; Chow, N-H; Ho, C-L
- Abstract
Oncofetal genes are expressed in embryos or fetuses, are downregulated or undetectable in adult tissues, and then re-expressed in tumors. Known oncofetal genes, such as AFP, GCB, FGF18, IMP-1 and SOX1, often have important clinical applications or pivotal biological functions. To find new oncofetal-like genes, we used the public information of expressed sequence tags to systematically analyze gene expression patterns and identified a novel oncofetal-like gene, LRRC16B. It increased the proliferation, anchorage-independent growth and tumorigenesis of transformed cells in xenografts, possibly through its effects on cyclin B1 protein levels. These findings exemplify the feasibility of using bioinformatics to find new oncofetal-like genes and suggest that more genes with important functional roles will be uncovered in the candidate gene list.
- Subjects
EMBRYOS; FETUS; GENE expression; BIOINFORMATICS; CARCINOGENESIS; XENOGRAFTS; CYCLINS
- Publication
Oncogene, 2011, Vol 30, Issue 6, p654
- ISSN
0950-9232
- Publication type
Article
- DOI
10.1038/onc.2010.451