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- Title
Renin is activated in monochorionic diamniotic twins with birthweight discordance who do not have twin-to-twin transfusion syndrome.
- Authors
Fujioka, K; Morioka, I; Miwa, A; Yokota, T; Matsuo, K; Morikawa, S; Enomoto, M; Shibata, A; Morizane, M; Yokoyama, N; Yamada, H; Matsuo, M
- Abstract
Objective:To assess renin, aldosterone, human atrial natriuretic peptide (hANP) and brain natriuretic peptide (BNP) levels in cord blood from monochorionic diamniotic (MD) twins with a birthweight (BW) discordance that do not satisfy the criteria of twin-to-twin transfusion syndrome (TTTS).Study Design:Cord blood samples were obtained from 28 MD twins without TTTS. They were divided into two groups on the basis of BW discordance as follows: large (>7.5%) and small (7.5%). Cord blood renin, aldosterone, hANP and BNP levels were measured.Result:Renin levels in MD twins with a large BW discordance were significantly higher than those in MD twins with a small BW discordance, with no significant differences in aldosterone, hANP and BNP levels. A significant correlation was found between renin levels and BW discordance.Conclusion:Renin is activated in MD twins with a BW discordance of >7.5%, even in non-TTTS.
- Subjects
ALDOSTERONE; BODY weight; CHI-squared test; CORD blood; FISHER exact test; PEPTIDE hormones; REGRESSION analysis; RENIN; TWINS; U-statistics; FETAL development; DESCRIPTIVE statistics
- Publication
Journal of Perinatology, 2012, Vol 32, Issue 7, p514
- ISSN
0743-8346
- Publication type
Article
- DOI
10.1038/jp.2011.136