We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Inhibition of NF-κB enhances the cytotoxicity of virus-directed enzyme prodrug therapy and oncolytic adenovirus cancer gene therapy.
- Authors
Palmer, D. H.; Chen, M-J.; Searle, P. F.; Kerr, D. J.; Young, L. S.
- Abstract
Virus-directed enzyme prodrug therapy utilizing the bacterial enzyme nitroreductase delivered by a replication-defective adenovirus vector to activate the prodrug CB1954 is a promising strategy currently undergoing clinical trials in patients with a range of cancers. Similarly, selectively replicating oncolytic adenoviruses are entering clinical trials. An understanding of interactions between vector and target cell are critical to the development of these strategies. We demonstrate that adenovirus vectors activate cellular pathways that promote cell survival in an NF-κB-dependent manner, and consequently have a negative effect on the efficacy of cell killing induced by cancer gene therapy strategies. This provides a potential therapeutic target to enhance the cytotoxicity of these approaches.Gene Therapy (2005) 12, 1187–1197. doi:10.1038/sj.gt.3302510; published online 31 March 2005
- Subjects
CELL-mediated cytotoxicity; ENZYMES; ADENOVIRUSES; DNA viruses; CANCER treatment; THERAPEUTICS
- Publication
Gene Therapy, 2005, Vol 12, Issue 15, p1187
- ISSN
0969-7128
- Publication type
Article
- DOI
10.1038/sj.gt.3302510