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- Title
Mechanism of Taiwan Mingjian Oolong Tea to Inhibit Isoproterenol-Induced Hypertrophy and Apoptosis in Cardiomyoblasts.
- Authors
Yeh, Yu-Lan; Tsai, Hsiang-I; Cheng, Shiu-Min; Pai, Peiying; Ho, Tsung-Jung; Chen, Ray-Jade; Lai, Chao-Hung; Huang, Pei-Jane; Padma, V. Vijaya; Huang, Chih-Yang
- Abstract
This study investigates the cardio-protective effect of Nos. 1 and 5 extracts from Taiwan Mingjian Oolong Tea on H9c2 cardiomyoblast cells treated with isoproterenol (ISO). Treatment with Nos. 1 and 5 extracts increased cell viability and blocked apoptosis in ISO exposed H9c2 cells. Moreover, Nos. 1 and 5 extracts blocked hypertrophy markers like Gs, calcineurin, NFATc3, and BNP, thereby increasing cell proliferation markers -PI3K and AKT in a dose dependent manner. In contrast, apoptotic proteins, such as caspase-3 and cytochrome c were decreased in H9c2 cells treated with Nos. 1 and 5 extracts. We confirmed that the protective effect of No. 1 extract was partially mediated through the expression of ERK and p38, however, the No. 5 extract showed a protective effect via the ERK, JNK, and p38 pathways. This evidence provides new insights into the pharmacological role and therapeutic mechanism of Taiwan Mingjian Oolong Tea in heart diseases.
- Subjects
CARDIOMYOPATHIES; THERAPEUTIC use of tea; ANIMAL experimentation; APOPTOSIS; CELLS; ISOPROTERENOL; RATS; RESEARCH funding; STATISTICS; PLANT extracts; DATA analysis; DATA analysis software; DESCRIPTIVE statistics; ONE-way analysis of variance; PREVENTION
- Publication
American Journal of Chinese Medicine, 2016, Vol 44, Issue 1, p77
- ISSN
0192-415X
- Publication type
Article
- DOI
10.1142/S0192415X16500051