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- Title
Anti-Inflammatory Activity of Schizonepeta tenuifolia through the Inhibition of MAPK Phosphorylation in Mouse Peritoneal Macrophages.
- Authors
Su-Jin Kim; Jung-Sun Kim; In-Young Choi; Dong-Hyun Kim; Min-Cheol Kim; Hyo-Jin An; Ho-Jeong Na; Na-Hyung Kim; Phil-Dong Moon; Noh-Yil Myung; Ju-Young Lee; Hyun-Ja Jeong; Jae-Young Um; Tae-Yong Shin; Hyung-Min Kim; Seung-Heon Hong
- Abstract
Schizonepeta tenuifolia (ST) is a well-known herb to treat the cold and its associated headache. However, the anti-inflammatory mechanism of ST in mouse peritoneal macrophages is not clear. In this study, we demonstrated that ST inhibited lipopolysaccaride (LPS)-induced tumor necrosis factor (TNF)-α and interleukin (IL)-6 production. The maximal inhibition rate of TNF-α and IL-6 production by ST (2 mg/ml) was 48.01 ± 2.8% and 56.45 ± 2.8%, respectively. During the inflammatory process, cyclooxygenase (COX)-2 and inducible nitric oxide synthase (iNOS) were increased in mouse peritoneal macrophages. However, treated with ST decreased the protein level of COX-2 and iNOS, as well as the production of PGE2 and NO in LPS-stimulated mouse peritoneal macrophages. In addition, ST inhibited the phosphorylation of MAPK. Taken together, the results of this study suggest an important molecular mechanism by which ST reduces inflammation, which may explain its beneficial effect in the regulation of inflammatory reactions.
- Subjects
HERBAL medicine; HEADACHE; ANTI-inflammatory agents; MACROPHAGES; ENDOTOXINS; TUMOR necrosis factors; INTERLEUKINS; NITRIC oxide
- Publication
American Journal of Chinese Medicine, 2008, Vol 36, Issue 6, p1145
- ISSN
0192-415X
- Publication type
Article
- DOI
10.1142/S0192415X0800648X