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- Title
Imaging central veins in brain lesions with 3-T T2*-weighted magnetic resonance imaging differentiates multiple sclerosis from microangiopathic brain lesions.
- Authors
Mistry, Niraj; Abdel-Fahim, Rasha; Samaraweera, Amal; Mougin, Olivier; Tallantyre, Emma; Tench, Christopher; Jaspan, Tim; Morris, Peter; Morgan, Paul S.; Evangelou, Nikos
- Abstract
Background: White matter lesions are frequently detected using brain magnetic resonance imaging (MRI) performed for various indications. Most are microangiopathic, but demyelination, including multiple sclerosis (MS), is an important cause; conventional MRI cannot always distinguish between these pathologies. The proportion of lesions with a central vein on 7-T T2*-weighted MRI prospectively distinguishes demyelination from microangiopathic lesions. Objective: To test whether 3-T T2*-weighted MRI can differentiate MS from microangiopathic brain lesions. Methods: A total of 40 patients were studied. Initially, a test cohort of 10 patients with MS and 10 patients with microangiopathic white matter lesions underwent 3-T T2*-weighted brain MRI. Anonymised scans were analysed blind to clinical data, and simple diagnostic rules were devised. These rules were applied to a validation cohort of 20 patients (13 with MS and 7 with microangiopathic lesions) by a blinded observer. Results: Within the test cohort, all patients with MS had central veins visible in >45% of brain lesions, while the rest had central veins visible in <45% of lesions. By applying diagnostic rules to the validation cohort, all remaining patients were correctly categorised. Conclusion: 3-T T2*-weighted brain MRI distinguishes perivenous MS lesions from microangiopathic lesions. Clinical application of this technique could supplement existing diagnostic algorithms.
- Subjects
BRAIN injuries; WHITE matter (Nerve tissue); MULTIPLE sclerosis diagnosis; BRAIN imaging; SENSITIVITY &; specificity (Statistics)
- Publication
Multiple Sclerosis Journal, 2016, Vol 22, Issue 10, p1289
- ISSN
1352-4585
- Publication type
Article
- DOI
10.1177/1352458515616700