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- Title
Behçet's disease and activities of daily living.
- Authors
Nagano, Aoi; Takeuchi, Masaki; Horita, Nobuyuki; Teshigawara, Takeshi; Kawagoe, Tatsukata; Mizuki, Yuki; Meguro, Akira; Nakano, Hiroto; Kirino, Yohei; Takase-Minegishi, Kaoru; Yoshimi, Ryusuke; Kurosawa, Michiko; Fukumoto, Takeshi; Takeno, Mitsuhiro; Kaneko, Takeshi; Mizuki, Nobuhisa
- Abstract
Objectives No large-scale registration study has comprehensively evaluated the activities of daily living (ADL) in patients with Behçet's disease. Methods The Japanese government provided us with a dataset of confirmed or suspected Behçet's disease cases derived from ongoing national registration. ADL were categorized and analysed into four categories in patients who satisfied the International Criteria for Behçet's Disease. Results Data from 2960 patients (men 38.9%, women 61.1%; median age 39 years) were assessed. While 1767 patients (59.7%) had normal ADL, the others had impaired ADL comprising limited but not assisted [ n = 1058 (35.7%)], partially assisted [ n = 116 (3.9%)] and fully assisted [ n = 19 (0.6%)]. Logistic regression analysis showed that chronic ocular lesions [odds ratio (OR) 1.85 (95% CI 1.46, 2.35), P < 0.001], paralysis [OR 2.51 (95% CI 1.58, 3.97), P < 0.001], psychosis [OR 3.16 (95% CI 2.02, 4.95), P < 0.001] and arthritis [OR 1.69 (95% CI 1.44, 1.99), P < 0.001] led to the risk of impaired ADL. Chronic ocular lesions [OR 3.61 (95% CI 2.27, 5.72), P < 0.001], paralysis [OR 3.43 (95% CI 1.87, 6.30), P < 0.001] and psychosis [OR 3.60 (95% CI 2.00, 6.50), P < 0.001] were related to the requirement of physical assistance (partially or fully assisted), although arthritis [OR 1.39 (95% CI 0.93, 2.06), P = 0.108] was not a significant factor in this model. Conclusion Ocular lesions, neurological manifestations and arthritis affected ADL. Patients with ocular lesions or neurological manifestations more frequently required physical assistance.
- Subjects
JAPAN; CONFIDENCE intervals; BEHCET'S disease; FUNCTIONAL status; PARALYSIS; PSYCHOSES; ACTIVITIES of daily living; NEUROLOGIC manifestations of general diseases; DESCRIPTIVE statistics; QUESTIONNAIRES; LOGISTIC regression analysis; ODDS ratio; ARTHRITIS; EYE diseases; HEALTH self-care; DISEASE complications
- Publication
Rheumatology, 2022, Vol 61, Issue 3, p1133
- ISSN
1462-0324
- Publication type
Article
- DOI
10.1093/rheumatology/keab499