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- Title
Atomic structures of Coxsackievirus A6 and its complex with a neutralizing antibody.
- Authors
Longfa Xu; Qingbing Zheng; Shaowei Li; Maozhou He; Yangtao Wu; Yongchao Li; Rui Zhu; Hai Yu; Qiyang Hong; Jie Jiang; Zizhen Li; Shuxuan Li; Huan Zhao; Lisheng Yang; Wangheng Hou; Wei Wang; Xiangzhong Ye; Jun Zhang; Baker, Timothy S.; Tong Cheng
- Abstract
Coxsackievirus A6 (CVA6) has recently emerged as a major cause of hand, foot and mouth disease in children worldwide but no vaccine is available against CVA6 infections. Here, we demonstrate the isolation of two forms of stable CVA6 particles-procapsid and A-particlewith excellent biochemical stability and natural antigenicity to serve as vaccine candidates. Despite the presence (in A-particle) or absence (in procapsid) of capsid-RNA interactions, the two CVA6 particles have essentially identical atomic capsid structures resembling the uncoating intermediates of other enteroviruses. Our near-atomic resolution structure of CVA6 A-particle complexed with a neutralizing antibody maps an immune-dominant neutralizing epitope to the surface loops of VP1. The structure-guided cell-based inhibition studies further demonstrate that these loops could serve as excellent targets for designing anti-CVA6 vaccines.
- Subjects
COXSACKIEVIRUSES; ATOMIC structure; HAND, foot &; mouth disease; VACCINES; EPITOPES
- Publication
Nature Communications, 2017, Vol 8, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-017-00477-9