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- Title
DEVELOPMENT AND VALIDATION OF SOME NEW UV-VISIBLE SPECTROPHOTOMETRIC METHODS FOR THE ASSAY OF INDINAVIR IN PURE AND DOSAGE FORMS.
- Authors
Parameswara Rao, K.; Srirangam, G. M.; Ramana, G. V.; Rao, M. C.
- Abstract
Some new selective accurate and economical spectrophotometric methods for the determination of Indinavir in pure and dosage forms have been described in the present work. These developed methods have been extended to pharmaceutical formulations as they are simple, economical and sensitive. The present methods involve the formation of highly stable colored species which makes it easier for the determination of Indinavir in pharmaceutical dosage at the given optimum conditions. The stock solution of Indinavir was prepared by dissolving100 mg of the pure Indinavir drug in 10.0 mL of methanol and made up to 100 mL with distilled water to get a clear solution. Appropriate volumes of this stock solution were diluted step wise to get the working standard solutions of concentrations 200 μg/mL for Method-M9, 240 μg/mL for Method-M11, M12 and 250 μg/mL for Method-M8, M13, M14 respectively. The effect of wide range of excipients and other inactive ingredients usually present in the formulations for the assay of Indinavir under optimum conditions were investigated. The values obtained by the proposed and reference method for formulations were compared statistically with F and t tests and found not to be different significantly. Percent recoveries were determined by adding standard drug to preanalyzed formulations.
- Subjects
SPECTROPHOTOMETRY; OPTICAL measurements; INDINAVIR; PHARMACEUTICAL arithmetic; METHANOL
- Publication
Rasayan Journal of Chemistry, 2016, Vol 9, Issue 3, p393
- ISSN
0974-1496
- Publication type
Article