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- Title
Association Between CYP2D6 Polymorphisms and Outcomes Among Women With Early Stage Breast Cancer Treated With Tamoxifen.
- Authors
Schroth, Werner; Goetz, Matthew P.; Hamann, Ute; Fasching, Peter A.; Schmidt, Marcus; Winter, Stefan; Fritz, Peter; Simon, Wolfgang; Suman, Vera J.; Ames, Matthew M.; Safgren, Stephanie L.; Kuffel, Mary J.; Ulmer, Hans Ulrich; Boländer, Julia; Strick, Reiner; Beckmann, Matthias W.; Koelbl, Heinz; Weinshilboum, Richard M.; Ingle, James N.; Eichelbaum, Michel
- Abstract
The article discusses a study which investigated the association between the polymorphic cytochrome P450 2D6 (CYP2D6) enzyme and the clinical outcomes in women receiving adjuvant tamoxifen for early stage breast cancer. German and U.S. cohorts of 1,325 patients who had diagnoses between 1986 and 2005 of stage I through III breast cancer were analyzed. The researchers found an association between CYP2D6 variation and clinical outcomes among women with hormone receptor-positive breast cancer treated with tamoxifen. A comment on the study is presented.
- Subjects
UNITED States; GERMANY; CYTOCHROME P-450; ADJUVANT treatment of cancer; TAMOXIFEN; BREAST cancer treatment; CANCER in women; CANCER treatment
- Publication
JAMA: Journal of the American Medical Association, 2009, Vol 302, Issue 13, p1429
- ISSN
0098-7484
- Publication type
Article
- DOI
10.1001/jama.2009.1420