We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Sex Steroids Affect Triglyceride Handling, Glucose-Dependent Insulinotropic Polypeptide, and Insulin Sensitivity.
- Authors
Lapauw, Bruno; Ouwens, Margriet; 'T Hart, Leen M.; Wuyts, Birgitte; Holst, Jens J.; T'Sjoen, Guy; Kaufman, Jean-Marc; Ruige, Johannes B.
- Abstract
OBJECTIVE -- To evaluate metabolic effects of sex steroids in nonfasting and fasting conditions, independent from changes in body composition. RESEARCH DESIGN AND METHODS -- A randomized clinical trial was performed to create contrasting sex steroid levels in healthy young men: by letrozole (aromatase inhibitor) to lower estradiol (E2) and increase testosterone (group T, n = 10) versus letrozole plus E2 patches to lower T and raise E2 (group E, n = 10). Mixed meals and hyperinsulinemic-euglycemic clamps were performed before and after a 1-week treatment period. RESULTS- Following intervention, the postprandial triglyceride response displayed a diverging response with a decline in group T and an increase in group E; the postprandial glucose-dependent insulinotropic polypeptide (GIP) response increased in group T. Insulin sensitivity increased in group T but remained unaltered in group E. CONCLUSIONS -- In healthy young men, short-term changes in sex steroids affect postprandial triglyceride and GIP response and insulin sensitivity.
- Subjects
STEROIDS; DRUG side effects; PEOPLE with diabetes; TRIGLYCERIDES; POLYPEPTIDES; INSULIN resistance; HEALTH
- Publication
Diabetes Care, 2010, Vol 33, Issue 8, p1831
- ISSN
0149-5992
- Publication type
Article
- DOI
10.2337/dc10-0515