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- Title
Exposure to Ozone Inhibits Isolation-Induced Aggressive Behavior of Adult CD-1 Male Mice.
- Authors
Petruzzi, S.; Fiore, M.; Dell'Omo, G.; Alleva, E.
- Abstract
Continuous exposure to ozone (O3, 1.2 ppm) in adult CD-1 male mice for 20 consecutive days markedly influenced a number of items of aggressive behavior induced by 59 days of individual housing. The behavior of mice was videotaped on days 1, 3, and 5 of five consecutive daily encounters (10 min each; isolation days 55, 57, and 59). Ozone exposure caused an abatement of aggressive behavior and enhanced fear-associated displays shown by a significant decrease in the frequency of attacking and digging and an increase in freezing. Moreover, O3 induced a decrease or time spent in attacking and exploration/activity. Nonexposed animals exhibited a day-dependent increase in self-grooming frequency which was not observed in O3 mice; by contrast, freezing was higher m O3 mice on day 5 of the lest. Data suggest that O3 exposure produces a remarkable reduction of mouse aggression, indirectly confirming previous findings on physical and neurobehavioral effects of O3.
- Subjects
AGGRESSION (Psychology); OZONE; MICE; ANIMAL aggression; ANIMAL models in research; ANIMAL housing; PHYSIOLOGICAL effects of ozone; ANIMAL behavior; LABORATORY mice; ANIMAL psychology
- Publication
Aggressive Behavior, 1995, Vol 21, Issue 5, p387
- ISSN
0096-140X
- Publication type
Article
- DOI
10.1002/1098-2337(1995)21:5<387::AID-AB2480210508>3.0.CO;2-0