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- Title
Imatinib Mesylate Resistance in a Chronic Myeloid Leukemia Patient with a Novel e8a2 BCR-ABL Transcript Variant.
- Authors
Ya Zhen Qin; Bin Jiang; Qian Jiang; Yan Zhang; Hao Jiang; Jin Lan Li; Hong Hu Zhu; Ling Di Li; Yan Rong Liu; Shan Shan Chen; Xiao Jun Huang
- Abstract
Background: The vast majority of chronic myeloid leukemia (CML) patients express the BCR-ABL transcript with the b2a2 (e13a2) and/or b3a2 (e14a2) junctions. However, some rare cases have atypical breakpoints. Methods and Results: We identified a CML patient with a unique e8a2 BCR-ABL transcript variant. It contained the first 114 nucleotides of BCR exon 8, with an insertion of 16 nucleotides from the 3′ end of ABL intron 1a, followed by ABL exon 2. Due to her uncontrolled thrombocytosis after 3 years of interferon-α treatment, the patient received imatinib at a dosage of 400 mg/day. Though achieving a sustained and complete hematological response after 3 months, she was resistant to imatinib during the entire 65-month imatinib treatment. That is, she failed to achieve major cytogenetic response and there was no significant decrease in her BCR-ABL transcript levels. Meanwhile, an M351T mutant was detected at 18 months after the start of imatinib treatment. Conclusion: ABL point mutation is also a mechanism of imatinib resistance for CML patients with the BCR-ABL transcript variant. Copyright © 2008 S. Karger AG, Basel
- Subjects
CHRONIC myeloid leukemia; NUCLEOTIDES; INTERFERONS; THERAPEUTICS; HEMATOLOGY; IMATINIB; CYTOGENETICS; PATIENTS
- Publication
Acta Haematologica, 2009, Vol 120, Issue 3, p146
- ISSN
0001-5792
- Publication type
Article
- DOI
10.1159/000178145