We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Increased Matrix Metalloproteinase-9 Predicts Poor Wound Healing in Diabetic Foot Ulcers.
- Authors
Liu, Yu; Min, Danqing; Bolton, Thyra; Nubé, Vanessa; Twigg, Stephen M.; Yue, Dennis K.; McLennan, Susan V.
- Abstract
OBJECTIVE -- We studied the relationships of diabetic ulcer wound fluid matrix metalloproteinases (MMPs), tissue inhibitors of metalloproteinases (TIMPs), and transforming growth factor-ßl (TGF-ßl) with wound healing rate. RESEARCH DESIGN AND METHODS-- The ulcers were cleansed to remove exudates, and wound fluids were collected for analysis of MMP-2 and -9, TIMP-1, and TGF-ßl. RESULTS-- At presentation, MMP-9 and the MMP-9-to-TIMP-1 ratio correlated inversely with the wound healing rate at 28 days (P < 0.001). MMP-9 and the MMP-9-to-TIMP-1 ratio were lower in the 23 patients who achieved complete healing at 12 weeks versus the 39 who did not. The pro-MMP-9 concentration was predictive of healing within 12 weeks. Addition of cutoffs for TIMP-1 (>480 pg/ml) and TGF-ß (>115 pg/ml) further improved its predictive power (area under the curve 0.94). CONCLUSIONS -- These findings suggest that a milieu with high MMP-9 may be indicative of inflammation and poor wound healing. Measurements of MMP-9, TIMP-1, and TGF-ß in wound fluid may help to identify ulcers at risk of poor healing.
- Subjects
METALLOPROTEINASES; WOUND healing; DIABETIC foot; TRANSFORMING growth factors; EXUDATES &; transudates
- Publication
Diabetes Care, 2009, Vol 32, Issue 1, p117
- ISSN
0149-5992
- Publication type
Article
- DOI
10.2337/dc08-0763