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- Title
Two cases of HLA-DR2-negative hypersomnia manifesting sleep-onset rapid eye movement periods in the multiple sleep latency test.
- Authors
Yoshida, Yasushi; Kuroda, Kenji; Mandai, Masaharu; Satani, Seiji; Emura, Narutsugu; Ueda, Satoshi; Matsumura, Hitoshi; Yoneda, Hiroshi
- Abstract
We encountered two cases expressing excessive daytime sleepiness (EDS) and manifesting two or more sleep-onset rapid eye movement (REM) periods in the multiple sleep latency test. Unbearable daytime sleepiness occurred abruptly, which usually led to short-lasting naps, after which the patients felt refreshed. The EDS was successfully reduced by treatment with methylphenidate. In spite of these features similar to narcolepsy, these cases of REM hypersomnia did not present cataplexy or other auxiliary symptoms of narcolepsy, and, furthermore, the class-II human leukocyte antigen DR2 appeared to be negative.
- Subjects
DROWSINESS; RAPID eye movement sleep; NARCOLEPSY
- Publication
Psychiatry & Clinical Neurosciences, 1999, Vol 53, Issue 2, p295
- ISSN
1323-1316
- Publication type
Article
- DOI
10.1046/j.1440-1819.1999.00525.x