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- Title
BREAst screening Tailored for HEr (BREATHE)—A study protocol on personalised risk-based breast cancer screening programme.
- Authors
Liu, Jenny; Ho, Peh Joo; Tan, Tricia Hui Ling; Yeoh, Yen Shing; Chew, Ying Jia; Mohamed Riza, Nur Khaliesah; Khng, Alexis Jiaying; Goh, Su-Ann; Wang, Yi; Oh, Han Boon; Chin, Chi Hui; Kwek, Sing Cheer; Zhang, Zhi Peng; Ong, Desmond Luan Seng; Quek, Swee Tian; Tan, Chuan Chien; Wee, Hwee Lin; Li, Jingmei; Iau, Philip Tsau Choong; Hartman, Mikael
- Abstract
Routine mammography screening is currently the standard tool for finding cancers at an early stage, when treatment is most successful. Current breast screening programmes are one-size-fits-all which all women above a certain age threshold are encouraged to participate. However, breast cancer risk varies by individual. The BREAst screening Tailored for HEr (BREATHE) study aims to assess acceptability of a comprehensive risk-based personalised breast screening in Singapore. Advancing beyond the current age-based screening paradigm, BREATHE integrates both genetic and non-genetic breast cancer risk prediction tools to personalise screening recommendations. BREATHE is a cohort study targeting to recruit ~3,500 women. The first recruitment visit will include questionnaires and a buccal cheek swab. After receiving a tailored breast cancer risk report, participants will attend an in-person risk review, followed by a final session assessing the acceptability of our risk stratification programme. Risk prediction is based on: a) Gail model (non-genetic), b) mammographic density and recall, c) BOADICEA predictions (breast cancer predisposition genes), and d) breast cancer polygenic risk score. For national implementation of personalised risk-based breast screening, exploration of the acceptability within the target populace is critical, in addition to validated predication tools. To our knowledge, this is the first study to implement a comprehensive risk-based mammography screening programme in Asia. The BREATHE study will provide essential data for policy implementation which will transform the health system to deliver a better health and healthcare outcomes.
- Subjects
SINGAPORE; ASIA; BREAST; MEDICAL screening; EARLY detection of cancer; BREAST cancer; BRCA genes; DISEASE risk factors
- Publication
PLoS ONE, 2022, Vol 17, Issue 3, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0265965