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- Title
INFLUENCE OF ASTAXANTHIN ADMINISTRATION ON HEPATIC OXIDATIVE STRESS MARKERS IN RATS INJECTED WITH METHYLNITROSUREA.
- Authors
Sanda, Andrei; Gal, A.; Pintea, Adela; Bedecean, Ioana; Arion, Alexandra; Baba, A. I.
- Abstract
Experimentally, in the oxidative stress state, the raising of the concentration of products resulted from oxidative degradation of lipids, proteins and nucleic acids have been notice, along with the decreasing of the enzymatic and nonenzymatie antioxidants activity. The literature shows a special interest on antioxidants characteristics of various vitamins and provitamines, especially carotenoids. The aim of this work is to highlight the markers of oxidative stress induce at the hepatic tissue level by methylnitrosurea (MNU) and also the manner in witch supplemented astaxanthin in the food diet can influence this markers. Methylnitrosurea, intraperitoneal injected in a unique dose in rats, causes hepatic lesions (chronicle hepatitis) and even hepatic tumors. Biochemical, MNU determines the appearance of oxidative stress at a hepatic level, fact proved by damaging the antioxidant enzymatic systems at the same time with the intensification of lipids and proteins oxidation processes. The results suggest that astaxanthin protects liver damage induced by MNU by inhibiting lipid and protein oxidation and stimulating the cellular antioxidant system.
- Subjects
OXIDATIVE stress; CHEMICAL inhibitors; BIOMOLECULES; OXIDATION; LIVER diseases; NUCLEIC acids; BILIARY tract
- Publication
Bulletin of the University of Agricultural Sciences & Veterinary Medicine Cluj-Napoca. Veterinary Medicine, 2008, Vol 65, Issue 1, p160
- ISSN
1843-5270
- Publication type
Article