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- Title
Inverse relationship of cardioankle vascular index with BMI in healthy Japanese subjects: a cross-sectional study.
- Authors
Daiji Nagayama; Haruki Imamura; Yuta Sato; Takashi Yamaguchi; Noriko Ban; Hidetoshi Kawana; Masahiro Ohira; Atsuhito Saiki; Kohji Shirai; Ichiro Tatsuno; Nagayama, Daiji; Imamura, Haruki; Sato, Yuta; Yamaguchi, Takashi; Ban, Noriko; Kawana, Hidetoshi; Ohira, Masahiro; Saiki, Atsuhito; Shirai, Kohji; Tatsuno, Ichiro
- Abstract
<bold>Objective: </bold>The objective of this study is to investigate the association of body mass index (BMI) with arterial stiffness assessed by cardioankle vascular index (CAVI).<bold>Subjects and Methods: </bold>A retrospective cross-sectional study was conducted in 23,257 healthy Japanese subjects (12,729 men and 10,528 women, aged 47.1 ± 12.5 years, BMI 22.9 ± 3.4 kg/m2) who underwent health screening between 2004 and 2006 in Japan. Exclusion criteria were current medication use and a past history of cardiovascular disease, hypertension, stroke, diabetes, and nephritis.<bold>Results: </bold>Male subjects showed significantly higher BMI, CAVI, and triglycerides and lower high-density lipoprotein (HDL)-cholesterol compared with female subjects. Next, the subjects were divided into tertiles of BMI: lower, middle, and upper, in a gender-specific manner. After adjusting for confounders including age, systolic blood pressure, and HDL-cholesterol identified by multiple regression analysis, the mean CAVI decreased progressively as BMI tertile increased in both genders. Furthermore, a negative inverse relationship between BMI and adjusted CAVI was observed throughout the BMI distribution. Multivariate logistic regression model for contributors of high CAVI (≥90th percentile) identified obesity (odds ratios (95% confidence interval): 0.804 (0.720-0.899)], older age [15.6 (14.0-17.4)], male gender [2.26 (2.03-2.51)], hypertension [2.28 (2.06-2.54)], impaired fasting glucose [1.17 (1.01-1.37)], and low HDL-cholesterol [0.843 (0.669-1.06)] as independent factors.<bold>Conclusion: </bold>We demonstrated an inverse relationship between CAVI and BMI in healthy Japanese subjects, suggesting that systemic accumulation of adipose tissue per se may lead to a linear decrease of arterial stiffness in nonobese and obese subjects without metabolic disorders.
- Subjects
JAPAN; ARTERIAL diseases; CARDIOVASCULAR system physiology; BODY mass index; HIGH density lipoproteins; JAPANESE people; ADIPOSE tissues; HEALTH; CARDIOVASCULAR disease diagnosis; HUMAN body composition; CARDIOVASCULAR diseases; HEALTH status indicators; MULTIVARIATE analysis; OBESITY; SEX distribution; LOGISTIC regression analysis; PREDICTIVE tests; DISEASE prevalence; HUMAN research subjects; CROSS-sectional method; RETROSPECTIVE studies; ANKLE brachial index; ODDS ratio; DIAGNOSIS
- Publication
Vascular Health & Risk Management, 2017, Vol 13, p1
- ISSN
1176-6344
- Publication type
journal article
- DOI
10.2147/VHRM.S119646