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- Title
Kinetics of Th17-related cytokine expression in experimentally induced rat periapical lesions.
- Authors
Wei, Shusheng; Kawashima, Nobuyuki; Suzuki, Noriyuki; Xu, Jing; Takahashi, Satomi; Zhou, Mengyu; Koizumi, Yu; Suda, Hideaki
- Abstract
Th17-related cytokines are essential factors in various pathological states, including inflammatory bone destruction. This study investigated the contribution of Th17-related cytokines to the progress of experimentally induced rat periapical lesions. Periapical pathoses were induced by unsealed exposure of the pulp chamber of the lower first molars. A variety of immunocompetent cells, including CD68+ macrophages, Ia antigen+ cells and TCRαβ+ T cells, were observed in the lesions. The expression levels of Th17-related cytokines, IL-17 and IL-23, and of pro-inflammatory cytokines, IL-1β and IL-6, were significantly increased at 14 days (expansion stage) compared with normal periapical tissues. The expression levels of Foxp3, a regulatory T cell ( Treg)-related gene, and of IL-10, an anti-inflammatory cytokine, were higher at 28 days (chronic stage) than at 14 days. These findings suggest that Th17-related cytokines may be primary contributors to the initiation of periapical bone destruction, and that lesion expansion may be regulated by anti-inflammatory mediators.
- Subjects
CYTOKINES; INTERLEUKIN-17; RAT diseases; DENTAL pulp cavities; IMMUNOCOMPETENT cells; MACROPHAGES
- Publication
Australian Endodontic Journal, 2013, Vol 39, Issue 3, p164
- ISSN
1329-1947
- Publication type
Article
- DOI
10.1111/j.1747-4477.2012.00371.x