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- Title
Modes of Brain Cell Death Following Intracerebral Hemorrhage.
- Authors
Zhang, Yan; Khan, Suliman; Liu, Yang; Zhang, Ruiyi; Li, Hongmin; Wu, Guofeng; Tang, Zhouping; Xue, Mengzhou; Yong, V. Wee
- Abstract
Intracerebral hemorrhage (ICH) is a devastating form of stroke with high rates of mortality and morbidity. It induces cell death that is responsible for neurological deficits postinjury. There are no therapies that effectively mitigate cell death to treat ICH. This review aims to summarize our knowledge of ICH-induced cell death with a focus on apoptosis and necrosis. We also discuss the involvement of ICH in recently described modes of cell death including necroptosis, pyroptosis, ferroptosis, autophagy, and parthanatos. We summarize treatment strategies to mitigate brain injury based on particular cell death pathways after ICH.
- Subjects
CEREBRAL hemorrhage; BRAIN death; BRAIN injuries; CELL death; PYROPTOSIS; NECROSIS
- Publication
Frontiers in Cellular Neuroscience, 2022, Vol 16, p1
- ISSN
1662-5102
- Publication type
Article
- DOI
10.3389/fncel.2022.799753