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- Title
Escherichia coli Dysbiosis Correlates With Gastrointestinal Dysfunction in Children With Cystic Fibrosis.
- Authors
Hoffman, Lucas R.; Pope, Christopher E.; Hayden, Hillary S.; Heltshe, Sonya; Levy, Roie; McNamara, Sharon; Jacobs, Michael A.; Rohmer, Laurence; Radey, Matthew; Ramsey, Bonnie W.; Brittnacher, Mitchell J.; Borenstein, Elhanan; Miller, Samuel I.
- Abstract
Cystic fibrosis gastrointestinal disease includes nutrient malabsorption and intestinal inflammation. We show that the abundances of Escherichia coli in fecal microbiota were significantly higher in young children with cystic fibrosis than in controls and correlated with fecal measures of nutrient malabsorption and inflammation, suggesting that E. coli could contribute to cystic fibrosis gastrointestinal dysfunction.
- Subjects
GASTROINTESTINAL diseases; CYSTIC fibrosis in children; MALABSORPTION syndromes; INFLAMMATORY bowel diseases; FECES; MICROBIOLOGY; ESCHERICHIA coli
- Publication
Clinical Infectious Diseases, 2014, Vol 58, Issue 3, p396
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/cit715