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- Title
Metabolomic screening and star pattern recognition by urinary amino acid profile analysis from bladder cancer patients.
- Authors
Jeong-Whun Kim; Gwang Lee; Seung-Min Moon; Myung-June Park; Sung Hong; Young-Hwan Ahn; Kyoung-Rae Kim; Man-Jeong Paik
- Abstract
Metabolomic analysis of urinary amino acids (AAs) from patients with bladder cancer was performed by gas chromatography–mass spectrometry. The β-aminoisobutyric acid ( P < 0.05) and pyroglutamic acid ( P < 0.03) levels among 21 AAs had relatively low P-values in the cancer group. The distorted star pattern of the cancer group was different from the heneicosagonal shape of the control mean. The present metabolomic screening combined with star pattern recognition method as clinical monitoring tool might be useful for the visual discrimination of bladder cancer group from normal group.
- Subjects
AMINO acid metabolism; BLADDER cancer; DIAGNOSIS; PROGNOSIS; GAS chromatography/Mass spectrometry (GC-MS); CANCER patients; URINALYSIS; DISEASE progression; DICHLOROMETHANE
- Publication
Metabolomics, 2010, Vol 6, Issue 2, p202
- ISSN
1573-3882
- Publication type
Article
- DOI
10.1007/s11306-010-0199-6