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- Title
Evaluation of the effectiveness of photodynamic therapy for the endodontic treatment of primary teeth: study protocol for a randomized controlled clinical trial.
- Authors
Costa da Mota, Ana Carolina; Gonçalves, Marcela Leticia Leal; Bortoletto, Carolina; Olivan, Silvia Regina; Salgueiro, Monica; Godoy, Camila; Altavista, Olga Maria; Pinto, Marcelo Mendes; Horliana, Anna Carolina; Motta, Lara J.; Bussadori, Sandra Kalil; da Mota, Ana Carolina Costa
- Abstract
<bold>Background: </bold>The elimination of pathogenic microorganisms from the root canal system is one of the major steps required for successful endodontic treatment. The aim of the proposed study is to conduct a randomized, controlled, clinical trial for the clinical and radiographic evaluation of the effectiveness of photodynamic therapy during the endodontic treatment of primary teeth.<bold>Methods: </bold>Thirty primary anterior teeth in children aged 3 to 6 years old will be randomly divided into 2 groups: a control group, which will receive conventional treatment, and an experimental group, which will be subjected to photodynamic therapy. Microbiological evaluations will be performed before and after endodontic treatment. Moreover, clinical and radiographic evaluations will be performed on the day of treatment as well as 1, 3 and 6 months after treatment. Comparisons will be made of the two study groups. The data will be tabulated and presented in a descriptive, analytical fashion. Depending on the distribution (normal or non-normal), either the t test, ANOVA or the Mann-Whitney test will be used for analysis of the variables. The Wilcoxon test will be used for comparisons before and after treatment. P values<0.05 (95% significance level) will be considered indicative of statistically significant differences.<bold>Discussion: </bold>As successful endodontic treatment is directly related to intra-canal bacterial disinfection and considering the difficult task of endodontic treatment in primary teeth, often due to difficulties in controlling young children, the internal anatomy of root canals and root resorption, the alternative of using PDT is a painless,easy-to-administer method that does not lead to microbial resistance and can assist in the achievement of successful endodontic treatment in primary teeth by eliminating the pain children can experience due to retreatment as well as premature tooth loss.<bold>Trial Registration: </bold>The protocol for this study was registered with Clinical Trials number NCT02485210 on 30 july 2015.
- Subjects
BRAZIL; PHOTODYNAMIC therapy; ENDODONTICS; DECIDUOUS teeth; RANDOMIZED controlled trials; PRESCHOOL children; WILCOXON signed-rank test; T-test (Statistics); MANN Whitney U Test; ANALYSIS of variance; CHILDREN'S dental care; COMPARATIVE studies; DENTAL pulp cavities; EXPERIMENTAL design; RESEARCH methodology; MEDICAL cooperation; RESEARCH protocols; METHYLENE blue; NONPARAMETRIC statistics; PERIAPICAL diseases; PHOTOCHEMOTHERAPY; PHOTOSENSITIZERS; RESEARCH; ROOT canal treatment; TIME; EVALUATION research; TREATMENT effectiveness; THERAPEUTICS
- Publication
Trials, 2015, Vol 16, Issue 1, p1
- ISSN
1745-6215
- Publication type
journal article
- DOI
10.1186/s13063-015-1086-2