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- Title
Galectin-1 expression in oral squamous cell carcinoma: An immunohistochemical study.
- Authors
Salunkhe, Vaibhavi; Mahajan, Aarti; Prakash, Nilima; Pradeep, G; Patil, Rekha; Gajdhar, Sajda
- Abstract
Context: Oral squamous cell carcinoma (OSCC) of the head and neck are a heterogeneous group of neoplasms with an increasing rate of mortality and morbidity. OSCCs are characterized by a high degree of local invasiveness and metastasis to cervical lymph nodes but show a lower rate of distant metastasis. Galectin-1 (Gal-1), a β-galactoside-binding lectin, is known to regulate tumor cell growth, angiogenesis, mediate cell-cell or cell-extracellular matrix adhesion and promote cancer cell migration. Aims: This study aims to evaluate the Gal-1 expression in different clinical stages and histological grades of OSCC. Settings and Design: Forty histopathologically diagnosed cases of OSCC, including 16 cases of well-differentiated, 18 moderately differentiated and 6 poorly differentiated carcinomas, were included in the study group. Materials and Methods: The samples were subjected to staining using primary mouse monoclonal antibodies against Gal-1 and visualized using polymer-HRP detection system. Statistical Analysis: The nonparametric Mann–Whitney U-test and Kruskal–Wallis ANOVA test were used for the statistical analysis. Results: Gal-1 expression was higher in advanced stages of OSCC, and the results were statistically significant. Immunoexpression of Gal-1 increased with advancing histological grades of OSCC with statistically significant results. Conclusion: Gal-1 plays an important role in invasion, metastasis and as a prognostic marker.
- Subjects
SQUAMOUS cell carcinoma; CELL-matrix adhesions; HISTOCHEMISTRY; CANCER cell migration; MONOCLONAL antibodies; KRUSKAL-Wallis Test; CELL growth
- Publication
Journal of Oral & Maxillofacial Pathology (0973029X), 2020, Vol 24, Issue 1, p186
- ISSN
0973-029X
- Publication type
Article
- DOI
10.4103/jomfp.JOMFP_240_19