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- Title
Protection against experimental infection with influenza virus A/equine/Miami/63 (H3N8) provided by inactivated whole virus vaccines containing homologous virus.
- Authors
Mumford, J. A.; Wood, J. M.; Folkers, C.; Schild, G. C.
- Abstract
Thirty-one ponies immunized with inactivated virus vaccine containing A/equine/Miami/63 (H3N8) virus and six seronegative ponies were experimentally challenged with the homologous virus strain. All G unvaccinated ponies and 11 out of 31 vaccinated ponies became infected. A clear relationship between pre-challenge antibody, measured by single radial haemolysis (SRH), and protection was demonstrated as judged by virus excretion, febrile responses and antibody responses. Those ponies with SRH antibody levels > 74 mm2 were completely protected against challenge infection by the intranasal route.
- Publication
Epidemiology & Infection, 1988, Vol 100, Issue 3, p501
- ISSN
0950-2688
- Publication type
Article
- DOI
10.1017/S0950268800067236