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- Title
The Effect of Deep Brain Stimulation on the Speech Motor System.
- Authors
Mücke, Doris; Becker, Johannes; Barbe, Michael T.; Meister, Ingo; Liebhart, Lena; Roettger, Timo B.; Dembek, Till; Timmermann, Lars; Grice, Martine
- Abstract
Purpose: Chronic deep brain stimulation of the nucleus ventralis intermedius is an effective treatment for individuals with medication-resistant essential tremor. However, these individuals report that stimulation has a deleterious effect on their speech. The present study investigates one important factor leading to these effects: the coordination of oral and glottal articulation. Method: Sixteen native-speaking German adults with essential tremor, between 26 and 86 years old, with and without chronic deep brain stimulation of the nucleus ventralis intermedius and 12 healthy, age-matched subjects were recorded performing a fast syllable repetition task (/papapa/, /tatata/, /kakaka/). Syllable duration and voicing-to- syllable ratio as well as parameters related directly to consonant production, voicing during constriction, and frication during constriction were measured. Results: Voicing during constriction was greater in subjects with essential tremor than in controls, indicating a perseveration of voicing into the voiceless consonant. Stimulation led to fewer voiceless intervals (voicing-to-syllable ratio), indicating a reduced degree of glottal abduction during the entire syllable cycle. Stimulation also induced incomplete oral closures (frication during constriction), indicating imprecise oral articulation. Conclusion: The detrimental effect of stimulation on the speech motor system can be quantified using acoustic measures at the subsyllabic level.
- Subjects
ARTICULATION disorders; CHI-squared test; HEALTH outcome assessment; SPEECH evaluation; STATISTICS; TREATMENT effectiveness; INTER-observer reliability; WAVE analysis; CASE-control method; DATA analysis software; DESCRIPTIVE statistics; DEEP brain stimulation; THERAPEUTICS
- Publication
Journal of Speech, Language & Hearing Research, 2014, Vol 57, Issue 4, p1206
- ISSN
1092-4388
- Publication type
Article
- DOI
10.1044/2014_JSLHR-S-13-0155