We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Relationship Between Circulating Retinol Binding Protein-4 Levels and Various Markers Related to Insulin Resistance or Diabetic Complications in Hospitalized Patients with Type 2 Diabetes.
- Authors
Takebayashi, Kohzo; Suetsugu, Mariko; Wakabayashi, Sadao; Aso, Yoshimasa; Inukai, Toshihiko
- Abstract
Retinal binding protein (RBP)-4 is a newly identified adipocytokine that can cause insulin resistance. The main purpose of the current study was to investigate the relationship between RBP4 and various markers related to insulin resistance, including triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), blood pressure (BP), endothelial function, oxidative stress, inflammation, and diabetic complications in patients with type 2 diabetes. The effect of pioglitazone (a thiazolidinedione) on RBP4 was also examined. Circulating RBP4 levels were measured in 101 hospitalized patients with type 2 diabetes and in 22 non-hospitalized control subjects. Endothelial function and oxidative stress were evaluated using flow-mediated vasodilatation (FMD) and urinary 8-iso-prostaglandin-F2α, respectively. Pioglitazone was administered for 12 weeks at a dose of 30 mg/day in a further 22 patient with type 2 diabetes in outpatient department. There was a significant elevation of RBP4 levels in diabetic patients compared with healthy subjects. RBP4 showed significant positive correlations with TG, systolic BP and log urinary albumin excretion (UAE), and significant negative correlations with HDL-C and FMD. By stepwise regression analysis log UAE, TG and gender showed a significant association with RBP4. There was a significant elevation of RBP4 in patients with proliferative-diabetic retinopathy compared with non-diabetic retinopathy and simple-diabetic retinopathy patients. Pioglitazone therapy for 12 weeks did not significantly affect the RBP4 concentration. In conclusion, this current study indicates the possibility that circulating RBP4 levels are associated with variables related to insulin resistance and diabetic complications.
- Subjects
VITAMIN A; CARRIER proteins; BIOMARKERS; INSULIN resistance; DIABETES complications; PEOPLE with diabetes; TYPE 2 diabetes
- Publication
Diabetes, 2007, Vol 56, pA588
- ISSN
0012-1797
- Publication type
Article