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- Title
Increase in Glucose-6-Phosphate Dehydrogenase in Adipocytes Stimulates Oxidative Stress and Inflammatory Signals.
- Authors
Jiyoung Park; Sung Sik Choe; A Hyun Choi; Kang Ho Kim; Myeong Jin Yoon; Suganami, Takayoshi; Ogawa, Yoshihiro; Jae Bum Kim
- Abstract
In adipocytes, oxidative stress and chronic inflammation are closely associated with metabolic disorders, including insulin resistance, obesity, cardiovascular disease, and type 2 diabetes. However, the molecular mechanisms underlying these metabolic disorders have not been thoroughly elucidated. In this report, we demonstrate that overexpression of glucose-6-phosphate dehydrogenase (G6PD) in adipocytes stimulates oxidative stress and inflammatory responses, thus affecting the neighboring macrophages. Adipogenic G6PD overexpression promotes the expression of pro-oxidative enzymes, including inducible nitric oxide synthase and NADPH oxidase, and the activation of nuclear factor-κB (NF-κB) signaling, which eventually leads to the dysregulation of adipocytokines and inflammatory signals. Furthermore, secretory factors from G6PD-overexpressing adipocytes stimulate macrophages to express more proinflammatory cytokines and to be recruited to the adipocytes; this would cause chronic inflammatory conditions in the adipose tissue of obesity. These effects of G6PD overexpression in adipocytes were abolished by pretreatment with NF-κB inhibitors or antioxidant drugs. Thus, we propose that a high level of G6PD in adipocytes may mediate the onset of metabolic disorders in obesity by increasing the oxidative stress and inflammatory signals. Diabetes 55:2939-2949, 2006
- Subjects
GLUCOSE; DEHYDROGENASES; FAT cells; OXIDATIVE stress; DIABETES complications
- Publication
Diabetes, 2006, Vol 55, Issue 11, p2939
- ISSN
0012-1797
- Publication type
Article
- DOI
10.2337/db05-1570