We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Healing of Skin Wounds in Rats Using Creams Based on Symphytum Officinale Extract.
- Authors
Mârza, Sorin Marian; Dăescu, Adela Maria; Purdoiu, Robert Cristian; Dragomir, Mădălina; Tătaru, Mariana; Melega, Iulia; Nagy, Andras-Laszlo; Gal, Adrian; Tăbăran, Flaviu; Bogdan, Sidonia; Moldovan, Mirela; Pall, Emoke; Munteanu, Camelia; Magyari, Klara; Papuc, Ionel
- Abstract
Rosmarinic acid is a well-known natural antioxidant and anti-inflammatory compound, and it is one of the polyphenolic compounds found in comfrey plants. Comfrey root also contains allantoin, which helps with new skin regeneration. This study aimed to investigate the healing and skin regeneration process of skin wounds in Wistar rats using creams based on comfrey extract and to correlate the results with active compounds in the extract. The obtained results showed that comfrey root is rich in bioactive compounds, including allantoin, salvianolic acid, and rosmarinic acid, which are known for their great free radical scavenging activity, and the high antioxidant activity of the extract may be mainly due to these compounds. The obtained extract has an antimicrobial effect on Staphylococcus aureus (1530.76/382.69), Escherichia coli (6123.01/6123.01), and Pseudomonas aeruginosa (6123.01/6123.01). The macroscopic evaluation and the histological analysis of the skin defects 14 days after the intervention showed faster healing and complete healing in the skin excisions treated with oil-in-water cream with 20% extract of comfrey as the active ingredient.
- Subjects
WOUND healing; SKIN injuries; ROSMARINIC acid; SKIN regeneration; RATS
- Publication
International Journal of Molecular Sciences, 2024, Vol 25, Issue 6, p3099
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms25063099