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- Title
Increased Prevalence of Unstable HLA-C Variants in HIV-1 Rapid-Progressor Patients.
- Authors
Stefani, Chiara; Sangalli, Antonella; Locatelli, Elena; Federico, Tania; Malerba, Giovanni; Romanelli, Maria Grazia; Argañaraz, Gustavo Adolfo; Da Silva, Bosco Christiano Maciel; Da Silva, Alberto Jose Duarte; Casseb, Jorge; Argañaraz, Enrique Roberto; Ruggiero, Alessandra; Zipeto, Donato
- Abstract
HIV-1 infection in the absence of treatment results in progression toward AIDS. Host genetic factors play a role in HIV-1 pathogenesis, but complete knowledge is not yet available. Since less-expressed HLA-C variants are associated with poor HIV-1 control and unstable HLA-C variants are associated with higher HIV-1 infectivity, we investigated whether there was a correlation between the different stages of HIV-1 progression and the presence of specific HLA-C allotypes. HLA-C genotyping was performed using allele-specific PCR by analyzing a treatment-naïve cohort of 96 HIV-1-infected patients from multicentric cohorts in the USA, Canada, and Brazil. HIV-1-positive subjects were classified according to their different disease progression status as progressors (Ps, n = 48), long-term non-progressors (LTNPs, n = 37), and elite controllers (ECs, n = 11). HLA-C variants were classified as stable or unstable according to their binding stability to β2-microglobulin/peptide complex. Our results showed a significant correlation between rapid progression to AIDS and the presence of two or one unstable HLA-C variants (p-value: 0.0078, p-value: 0.0143, respectively). These findings strongly suggest a link between unstable HLA-C variants both at genotype and at allele levels and rapid progression to AIDS. This work provides further insights into the impact of host genetic factors on AIDS progression.
- Subjects
BRAZIL; CANADA; HISTOCOMPATIBILITY class I antigens; HIV; LONG-term non-progressors; AIDS; DISEASE progression
- Publication
International Journal of Molecular Sciences, 2022, Vol 23, Issue 23, p14852
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms232314852