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- Title
Beyond Conventional: The New Horizon of Anti-Angiogenic microRNAs in Non-Small Cell Lung Cancer Therapy.
- Authors
Tirpe, Alexandru; Gulei, Diana; Tirpe, George Razvan; Nutu, Andreea; Irimie, Alexandru; Campomenosi, Paola; Pop, Laura Ancuta; Berindan-Neagoe, Ioana
- Abstract
GLOBOCAN 2018 identified lung cancer as the leading oncological pathology in terms of incidence and mortality rates. Angiogenesis is a key adaptive mechanism of numerous malignancies that promotes metastatic spread in view of the dependency of cancer cells on nutrients and oxygen, favoring invasion. Limitation of the angiogenic process could significantly hamper the disease advancement through starvation of the primary tumor and impairment of metastatic spread. This review explores the basic molecular mechanisms of non-small cell lung cancer (NSCLC) angiogenesis, and discusses the influences of the key proangiogenic factors—the vascular endothelial growth factor-A (VEGF-A), basic fibroblast growth factor (FGF2), several matrix metalloproteinases (MMPs—MMP-2, MMP-7, MMP-9) and hypoxia—and the therapeutic implications of microRNAs (miRNAs, miRs) throughout the entire process, while also providing critical reviews of a number of microRNAs, with a focus on miR-126, miR-182, miR-155, miR-21 and let-7b. Finally, current conventional NSCLC anti-angiogenics—bevacizumab, ramucirumab and nintedanib—are briefly summarized through the lens of evidence-based medicine.
- Subjects
NON-small-cell lung carcinoma; MICRORNA; FIBROBLAST growth factor 2; CANCER treatment; LUNG cancer; HYPOXIA-inducible factor 1
- Publication
International Journal of Molecular Sciences, 2020, Vol 21, Issue 21, p8002
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms21218002