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- Title
Pan-HDAC Inhibitors Promote Tau Aggregation by Increasing the Level of Acetylated Tau.
- Authors
Jeong, Hyeanjeong; Shin, Seulgi; Lee, Jun-Seok; Lee, Soo Hyun; Baik, Ja-Hyun; Lim, Sungsu; Kim, Yun Kyung
- Abstract
Epigenetic remodeling via histone acetylation has become a popular therapeutic strategy to treat Alzheimer's disease (AD). In particular, histone deacetylase (HDAC) inhibitors including M344 and SAHA have been elucidated to be new drug candidates for AD, improving cognitive abilities impaired in AD mouse models. Although emerged as a promising target for AD, most of the HDAC inhibitors are poorly selective and could cause unwanted side effects. Here we show that tau is one of the cytosolic substrates of HDAC and the treatment of HDAC inhibitors such as Scriptaid, M344, BML281, and SAHA could increase the level of acetylated tau, resulting in the activation of tau pathology.
- Publication
International Journal of Molecular Sciences, 2019, Vol 20, Issue 17, p4283
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms20174283