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- Title
Chemokine Signaling in Chemotherapy-Induced Neuropathic Pain.
- Authors
Brandolini, Laura; d'Angelo, Michele; Antonosante, Andrea; Cimini, Annamaria; Allegretti, Marcello
- Abstract
Chemotherapy-induced peripheral neuropathy (CIPN) is a side effect of chemotherapics such as taxanes, vinca alkaloids, and platinum compounds. In recent years, several reports have indicated the involvement of different molecular mechanisms in CIPN. The pathways described so far are diverse and target various components of the peripheral Nervous System (PNS). Among the contributors to neuropathic pain, inflammation has been indicated as a powerful driver of CIPN. Several pieces of evidence have demonstrated a chemotherapy-induced increase in peripheral pro-inflammatory cytokines and a strong correlation with peripheral neuropathy. At present, there are not adequate strategies to prevent CIPN, although there are drugs for treating CIPN, such as duloxetine, that have displayed a moderate effect on CIPN. In this review, we focus on the players involved in CIPN with a particular emphasis on chemokine signaling.
- Subjects
PERIPHERAL nervous system; DRUG side effects; PERIPHERAL neuropathy; PLATINUM compounds; CHEMOKINES; PAIN
- Publication
International Journal of Molecular Sciences, 2019, Vol 20, Issue 12, p2904
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms20122904