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- Title
Oral Administration of Surface-Deacetylated Chitin Nanofibers and Chitosan Inhibit 5-Fluorouracil-Induced Intestinal Mucositis in Mice.
- Authors
Ryo Koizumi; Kazuo Azuma; Hironori Izawa; Minoru Morimoto; Kosuke Ochi; Takeshi Tsuka; Tomohiro Imagawa; Tomohiro Osaki; Norihiko Ito; Yoshiharu Okamoto; Hiroyuki Saimoto; Shinsuke Ifuku
- Abstract
This study investigated the prophylactic effects of orally administered surface-deacetylated chitin nanofibers (SDACNFs) and chitosan against 5-fluorouracil (5-FU)-induced intestinal mucositis, which is a common side effect of 5-FU chemotherapy. SDACNFs and chitosan abolished histological abnormalities associated with intestinal mucositis and suppressed hypoproliferation and apoptosis of intestinal crypt cells. These results indicate that SDACNF and chitosan are useful agents for preventing mucositis induced by anti-cancer drugs.
- Subjects
NANOFIBERS; CHITIN; CHITOSAN; MUCOSITIS; INTESTINAL disease treatment; LABORATORY mice; MICE physiology; THERAPEUTICS
- Publication
International Journal of Molecular Sciences, 2017, Vol 18, Issue 2, p279
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms18020279