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- Title
Berteroin Present in Cruciferous Vegetables Exerts Potent Anti-Inflammatory Properties in Murine Macrophages and Mouse Skin.
- Authors
Yoo Jin Jung; Jae In Jung; Han Jin Cho; Myung-Sook Choi; Mi-Kyung Sung; Rina Yu; Young-Hee Kang; Jung Han Yoon Park
- Abstract
Berteroin (5-methylthiopentyl isothiocyanate) is a sulforaphane analog present in cruciferous vegetables, including Chinese cabbage, rucola salad leaves, and mustard oil. We examined whether berteroin exerts anti-inflammatory activities using lipopolysaccharide (LPS)-stimulated Raw 264.7 macrophages and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse skin inflammation models. Berteroin decreased LPS-induced release of inflammatory mediators and pro-inflammatory cytokines in Raw 264.7 macrophages. Berteroin inhibited LPS-induced degradation of inhibitor of Ba (IBa) and nuclear factor-B p65 translocation to the nucleus and DNA binding activity. Furthermore, berteroin suppressed degradation of IL-1 receptor-associated kinase and phosphorylation of transforming growth factor ß activated kinase-1. Berteroin also inhibited LPS-induced phosphorylation of p38 MAPK, ERK1/2, and AKT. In the mouse ear, berteroin effectively suppressed TPA-induced edema formation and down-regulated iNOS and COX-2 expression as well as phosphorylation of AKT and ERK1/2. These results demonstrate that berteroin exhibits potent anti-inflammatory properties and suggest that berteroin can be developed as a skin anti-inflammatory agent.
- Subjects
NF-kappa B; LABORATORY mice; ANTI-inflammatory agents; MACROPHAGES; SULFORAPHANE; BRASSICACEAE; MUSTARD oils
- Publication
International Journal of Molecular Sciences, 2014, Vol 15, Issue 11, p20686
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms151120686