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- Title
Poly (ADP-ribose) polymerase-1 haplotypes are associated with coeliac disease.
- Authors
Rueda, B.; Koeleman, B. P. C.; López-Nevot, M. A.; Ortega, E.; Maldonado, J.; López, M.; Polanco, I.; Martín, J.
- Abstract
In coeliac disease (CD) there is an inflammatory status of the intestinal mucosa because of a high expression of proinflammatory mediators. The nuclear protein poly (ADP-ribose) polymerase-1 (PARP-1) has been implicated in the initial inflammatory response by modulating transcription of inflammation-related genes. The aim of this work was to investigate the role of PARP-1 gene promoter region haplotypes in relation to coeliac disease susceptibility. We analysed a coeliac population consisting of a case-control panel with 120 CD patients and 311 healthy blood donors. A CA microsatellite, as haplotype-defining variant of the whole PARP-1 promoter, was typed using a polymerase chain reaction (PCR) method combined with fluorescence technology. We considered two promoter haplotypes: A defined by short CA alleles (83–87 bp) and B defined by long CA alleles (89–101 bp). Haplotype A was significantly increased within the coeliac patients group ( P = 0.007 OR 1.6 95%CI 1.12–2.35). Additionally, we observed a significant dose effect, showing homozygous individuals for haplotype A higher risk for CD susceptibility ( P = 0.007, OR 1.79 95%CI 1.14–2.82). Our results provide the first evidence that PARP-1 haplotypes are related with coeliac disease susceptibility.
- Subjects
CELIAC disease; ADENOSINE diphosphate; INFLAMMATION; INTESTINAL mucosa; INFLAMMATORY mediators; DIGESTIVE system diseases
- Publication
International Journal of Immunogenetics, 2005, Vol 32, Issue 4, p245
- ISSN
1744-3121
- Publication type
Article
- DOI
10.1111/j.1744-313X.2005.00521.x