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- Title
LIGHT AND ELECTRON MICROSCOPIC STUDIES OF EXPERIMENTALLYINDUCED PATHOLOGIC CHANGES IN THE RAT PERIODONTAL TISSUE.
- Authors
IJUHIN, N.
- Abstract
Morphological changes in periodontal tissues following topical application of lipopolysaccharide (LPS) or prostaglandin E2 (PGE2) were examined in Wistar rats by light and electron microscopy. Ultra-structural demonstration of acid phosphatase and immunohistochemical localization of lysozyme in these tissues were also studied. The number of osteoclasts along the alveolar bone facing the periodontal ligament was counted. After topical application of LPS, degeneration and necrosis of the junctional epithelial cells, gingival fibroblasts, and alveolar osteoblasts were observed, as were increased bone resorption by osteoclasts and enhanced phagocytosis of collagen fibrils by fibroblasts. LPS appears to traverse easily through the junctional epithelium into the underlying gingival connective tissues. There it can cause destruction of deeper periodontal tissues by activating alveolar bone resorption and by enhancing the phagocytosis of collagen fibrils. PGE2 topically applied induced similar morphological changes. Possible participation of PGE2 in the induction of these LPS-related changes is discussed.
- Subjects
DENTAL research; ELECTRON microscopy; LABORATORY rats; PERIODONTIUM; GINGIVA; PATHOLOGY
- Publication
Advances in Dental Research, 1988, Vol 2, Issue 2, p209
- ISSN
0895-9374
- Publication type
Article
- DOI
10.1177/08959374880020020301